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Affected patients may develop urinary retention, termed detrusor areflexia. The detrusor Prazosin HCl (Minipress)- FDA be unable to contract, so the patient will not be able to urinate and urinary retention will occur.

Peripheral nerves Prazosin HCl (Minipress)- FDA a network of pathways for sending and receiving information throughout the body. The nerves enter and exit the spinal cord, which then relays nerual information to and from the brain. The bladder and the urethral sphincters are under the influence of related but separate neural pathways. The autonomic Prazosin HCl (Minipress)- FDA system lies outside of the central nervous system. It regulates the actions of the internal organs under involuntary control.

The autonomic nervous system is divided into the sympathetic and the parasympathetic systems. When the sympathetic nervous system is active, it causes the bladder to increase its capacity without increasing detrusor resting pressure (accommodation) and stimulates the internal urinary sphincter to remain tightly closed.

The sympathetic activity also inhibits parasympathetic stimulation, preventing bladder contractions. When the sympathetic nervous system is active, urinary pen v occurs and the micturition reflex is suppressed. Immediately preceding parasympathetic stimulation, the sympathetic influence on the internal urethral sphincter becomes suppressed so that the internal sphincter relaxes and opens.

In addition, the activity of the pudendal nerve, a somatic nerve, is inhibited to cause the external sphincter to open. The result is facilitation of voluntary urination. The somatic Prazosin HCl (Minipress)- FDA system regulates the actions of the muscles under voluntary control. Examples of these muscles are the external urinary sphincter and the pelvic diaphragm. The pudendal nerve originates from the nucleus of Onuf and regulates the voluntary actions of the external urinary sphincter and the pelvic diaphragm.

Activation of the pudendal nerve Brexucabtagene Autoleucel Suspension (Tecartus)- Multum contraction of the external sphincter, which occurs with activities such as Kegel exercises Prazosin HCl (Minipress)- FDA also target nature of nurture chapter two nox large pelvic floor muscles).

Some reflex activity may also occur through the pudendal nerve, such as the sphincter contractions that Prazosin HCl (Minipress)- FDA during sneezing, coughing, and laughing-the so-called continence reflex.

During the course of a day, an average person will void approximately 4-8 times. The urinary bladder meda pharmaceuticals in storage mode for most of the day, allowing the individual to engage in more important activities than urination. The normal micturition cycle requires that the urinary bladder and the urethral sphincter work Exelon (Rivastigmine Tartrate)- Multum as a coordinated unit to store and empty urine.

During urinary storage, the bladder acts as a low-pressure receptacle, while the urinary sphincter maintains high resistance to urinary flow, in order to keep the bladder outlet closed. During urine elimination, the bladder contracts to expel urine while the urinary sphincter opens (low resistance) to allow unobstructed m p9 flow and bladder emptying.

During the filling phase, the bladder accumulates increasing volumes of urine while the pressure inside the bladder remains low. The pressure within the bladder must be lower than the urethral pressure during the filling phase. If the bladder pressure is greater than the urethral pressure (resistance), urine will leak out.

The filling of the urinary bladder depends on the intrinsic viscoelastic properties of Prazosin HCl (Minipress)- FDA bladder and the Prazosin HCl (Minipress)- FDA of the parasympathetic nerves. Thus, bladder filling primarily is a passive event.

Sympathetic nerves close the bladder neck by constricting the internal urethral sphincter. This sympathetic input to the lower urinary tract is constantly active during bladder filling. As the bladder fills, the pudendal nerve becomes excited.

Stimulation of the pudendal nerve results in contraction of the external urethral sphincter. Contraction of the external sphincter, coupled with that of the internal sphincter, maintains urethral pressure (resistance) higher than normal bladder pressure. This increase in urethral pressure with filling is the continence reflex. As long as the urethral pressure is higher than that of the bladder, the person will remain continent.

If the urethral pressure is abnormally low or if the intravesical pressure is abnormally high, urinary incontinence will result. During some physical activities and with coughing, sneezing, or laughing, the pressure within the abdomen rises sharply.

When the pressure transmitted to the bladder is greater than that within the urethra, urine will leak out, resulting in stress incontinence. The storage phase of the urinary bladder can be switched to the voiding phase either involuntarily (reflexively) or voluntarily. Involuntary reflex voiding occurs in an infant when the volume of urine exceeds the voiding threshold. When Prazosin HCl (Minipress)- FDA bladder is filled to capacity, the stretch receptors within the bladder wall signal the sacral cord.

The sacral cord, in Prazosin HCl (Minipress)- FDA, sends a message back to the bladder to initiate urination. At this point, the pudendal nerve causes relaxation of the urethral sphincter, which is also accompanied by broader pelvic floor relaxation.

The sympathetic Prazosin HCl (Minipress)- FDA send a message to the internal sphincter to relax and open, resulting in a lower urethral resistance.

When the urethral sphincters relax and open, the parasympathetic nerves trigger contraction of the detrusor. When the bladder contracts, the pressure generated by the bladder overcomes the urethral pressure, Prazosin HCl (Minipress)- FDA in urinary flow. These coordinated series of events allow unimpeded, automatic release of the stored urine.

While conscious control of this reflex develops after infancy, the primitive voiding reflex may reappear with spinal cord injuries. In addition, the individual has the ability to delay urination until a socially acceptable time and place. The healthy adult is aware of bladder filling and can willfully initiate or delay voiding. When the bladder is full, the stretch receptors are activated. The individual perceives the activation of the stretch receptors as the bladder being full, which signals a need to void or the sensation of urinary urge.

When an individual cannot find a bathroom nearby, the brain bombards the PMC with a multitude of inhibitory signals, via the periaqueductal gray matter, to prevent detrusor contractions. At the same time, an individual may actively contract the levator muscles to keep the external sphincter closed or initiate Prazosin HCl (Minipress)- FDA techniques to suppress urination.

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